MK-5108

DB12556InvestigationalSmall molecule

MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumors.

Chemical structure of MK-5108
Mechanism
Curator reviewed
Formula / weight
C22H21ClFN3O3S · 461.94 g/mol (avg)
Code names
MK 5108 · VX-689

Resolves to

Compound
UNIIH8J407531SCAS1010085-13-8ChEMBLCHEMBL3600873PubChem24748204
Structure
InChIKeyLCVIRAZGMYMNNT-VVONHTQRSA-NSMILESOC(=O)[C@@]1(CC2=CC=CC(NC3=NC=CS3)=N2)CC[C@@H](CC1)OC1=C(F)C(Cl)=CC=C1
Targets
O14965AURKAQ96GD4AURKB

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1Clinical trialPhase, status and sponsor resolved per trial
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4+ReferencesStructured and connected to the statements they support
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Which drugs share a target with MK-5108, and which of those have an active Phase 3 trial?

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