Peptidyl-prolyl cis-trans isomerase A

BE0001014ProteinHumansPPIA

Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563). It is acted on by 14 drugs in DrugBank.

Gene name
PPIA
UniProtKB entry
P62937Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
165 residues · 18,012 Da
Also known as
5.2.1.8 · Cyclophilin A · Cyclosporin A-binding protein · CYPA · PPIase A

Resolves to

Protein
UniProtP62937UniProt namePPIA_HUMAN
Gene
HGNCHGNC:9253NCBI Gene5478GenBank30309GeneCardsPPIA
Pharmacology
IUPHAR/GtoPdb2751KEGGhsa:5478
Structure
PDB1AK4PDB1AWQPDB1AWR
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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28GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidyl-prolyl cis-trans isomerase A, how selective are they, and which programs against it are still in active trials?

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