Interleukin-1 beta
Details
- Name
- Interleukin-1 beta
- Kind
- protein
- Synonyms
- Catabolin
- IL-1 beta
- IL1F2
- Gene Name
- IL1B
- UniProtKB Entry
- P01584Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0010736|Interleukin-1 beta MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST SQAENMPVFLGGTKGGQDITDFTMQFVSS
- Number of residues
- 269
- Molecular Weight
- 30747.7
- Theoretical pI
- 4.45
- GO Classification
- Functionsintegrin bindingProcessesastrocyte activation / cellular response to interleukin-17 / cellular response to lipopolysaccharide / cellular response to xenobiotic stimulus / defense response to Gram-positive bacterium / immune response / interleukin-1-mediated signaling pathway / JNK cascade / negative regulation of cell population proliferation / negative regulation of gap junction assembly / negative regulation of glucose transmembrane transport / negative regulation of neurogenesis / negative regulation of synaptic transmission / positive regulation of canonical NF-kappaB signal transduction / positive regulation of cell division / positive regulation of cell migration / positive regulation of cell population proliferation / positive regulation of complement activation / positive regulation of DNA-binding transcription factor activity / positive regulation of DNA-templated transcription / positive regulation of epithelial to mesenchymal transition / positive regulation of glial cell proliferation / positive regulation of inflammatory response / positive regulation of interleukin-2 production / positive regulation of MAP kinase activity / positive regulation of neuroinflammatory response / positive regulation of non-canonical NF-kappaB signal transduction / positive regulation of p38MAPK cascade / positive regulation of prostaglandin biosynthetic process / positive regulation of RNA biosynthetic process / positive regulation of T-helper 1 cell cytokine production / positive regulation of transcription by RNA polymerase II / positive regulation of type II interferon production / regulation of canonical NF-kappaB signal transduction / regulation of defense response to virus by host / regulation of ERK1 and ERK2 cascade / regulation of neurogenesis / regulation of nitric-oxide synthase activity / response to carbohydrate / response to interleukin-1 / response to lipopolysaccharide / vascular endothelial growth factor production
- General Function
- Potent pro-inflammatory cytokine (PubMed:10653850, PubMed:12794819, PubMed:28331908, PubMed:3920526). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744). Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection (PubMed:28331908)
- Specific Function
- cytokine activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm, cytosol
- Gene sequence
>lcl|BSEQ0010737|Interleukin-1 beta (IL1B) ATGGCAGAAGTACCTGAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAGGAT GACTTGTTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGAC CTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGC TTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCC TGCCCACAGACCTTCCAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAA GAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTACGA TCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATAT GAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATG TCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAGGAA AAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGT GTAGATCCCAAAAATTACCCAAAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATA GAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGGTACATCAGCACC TCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCGGCCAGGATATAACT GACTTCACCATGCAATTTGTGTCTTCCTAA
- Chromosome Location
- 2
- Locus
- 2q14.1
- External Identifiers
Resource Link UniProtKB ID P01584 UniProtKB Entry Name IL1B_HUMAN GenBank Protein ID 307043 GenBank Gene ID K02770 GeneCard ID IL1B GenAtlas ID IL1B HGNC ID HGNC:5992 PDB ID(s) 1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3LTQ, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAF, 4GAI, 4I1B, 5BVP, 5I1B, 5MVZ, 5R7W, 5R85, 5R86, 5R87, 5R88, 5R89, 5R8A, 5R8B, 5R8C, 5R8D, 5R8E, 5R8F, 5R8G, 5R8H, 5R8I, 5R8J, 5R8K, 5R8L, 5R8M, 5R8N, 5R8O, 5R8P, 5R8Q, 6I1B, 6Y8I, 6Y8M, 7CHY, 7CHZ, 7I1B, 7Z4T, 8C3U, 8RYK, 8RYS, 8RZB, 9ILB KEGG ID hsa:3553 NCBI Gene ID 3553 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Minocycline approved, investigational unknown target modulator Details Talmapimod investigational unknown target Details Etiprednol dicloacetate investigational unknown target Details VP025 investigational unknown target Details VX-702 investigational unknown target Details Andrographolide investigational unknown target Details VX-765 investigational unknown target Details Gevokizumab investigational unknown target Details Canakinumab approved, investigational yes target binderantibody Details Rilonacept approved, investigational yes target binder Details Dilmapimod investigational unknown target Details Foreskin keratinocyte (neonatal) approved yes target agonist Details Donepezil approved unknown target inhibitorinducer Details Celastrol investigational yes target suppressor Details TT-301 investigational yes target inhibitor Details Gallium nitrate approved, investigational yes target inhibitor Details Glucosamine approved, investigational yes target inhibitor Details Diacerein approved, investigational yes target inhibitor Details