Gap junction alpha-1 protein

BE0001095ProteinHumansGJA1

Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells... It is acted on by 8 drugs in DrugBank.

Gene name
GJA1
UniProtKB entry
P17302Swiss-Prot
Cellular location
Cell membrane
Residues / weight
382 residues · 43,008 Da
Also known as
Connexin-43 · Cx43 · Gap junction 43 kDa heart protein · GJAL

Resolves to

Protein
UniProtP17302UniProt nameCXA1_HUMAN
Gene
HGNCHGNC:4274NCBI Gene2697GenBank29917GeneCardsGJA1
Pharmacology
KEGGhsa:2697
Structure
PDB2LL2PDB7F92PDB7F93
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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51GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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55+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gap junction alpha-1 protein, how selective are they, and which programs against it are still in active trials?

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