Gap junction alpha-1 protein
Details
- Name
- Gap junction alpha-1 protein
- Kind
- protein
- Synonyms
- Connexin-43
- Cx43
- Gap junction 43 kDa heart protein
- GJAL
- Gene Name
- GJA1
- UniProtKB Entry
- P17302Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0010767|Gap junction alpha-1 protein MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRN YNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVD QRPSSRASSRASSRPRPDDLEI
- Number of residues
- 382
- Molecular Weight
- 43008.005
- Theoretical pI
- 8.98
- GO Classification
- Functionsalpha-tubulin binding / beta-catenin binding / beta-tubulin binding / efflux transmembrane transporter activity / gap junction hemi-channel activity / glutathione transmembrane transporter activity / monoatomic ion transmembrane transporter activity / protein tyrosine kinase binding / scaffold protein binding / signaling receptor binding / tubulin bindingProcessesadult heart development / atrial ventricular junction remodeling / blood vessel morphogenesis / bone development / bone remodeling / cardiac conduction system development / cell communication by chemical coupling / cellular response to amyloid-beta / cellular response to pH / columnar/cuboidal epithelial cell maturation / embryonic digit morphogenesis / establishment of mitotic spindle orientation / export across plasma membrane / glutamate secretion / heart looping / in utero embryonic development / lens development in camera-type eye / maintenance of blood-brain barrier / male gonad development / microtubule-based transport / milk ejection reflex / monoatomic ion transmembrane transport / negative regulation of gene expression / negative regulation of gonadotropin secretion / negative regulation of trophoblast cell migration / neuroblast migration / neuron migration / osteoblast differentiation / positive regulation of canonical NF-kappaB signal transduction / positive regulation of cold-induced thermogenesis / positive regulation of gene expression / positive regulation of mesodermal cell differentiation / positive regulation of morphogenesis of an epithelium / positive regulation of stem cell proliferation / positive regulation of striated muscle tissue development / positive regulation of vascular associated smooth muscle cell proliferation / protein localization / regulation of atrial cardiac muscle cell membrane depolarization / regulation of bone mineralization / regulation of bone remodeling / regulation of ventricular cardiac muscle cell membrane depolarization / regulation of ventricular cardiac muscle cell membrane repolarization / skeletal muscle tissue regeneration / spermatogenesis / T cell proliferation / xenobiotic transportComponentsapical plasma membrane / cell junction / cell-cell contact zone / connexin complex / contractile muscle fiber / cytoplasm / intermediate filament / intracellular membrane-bounded organelle / lateral plasma membrane / nucleoplasm / nucleus / tight junction
- General Function
- Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity)
- Specific Function
- alpha-tubulin binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 24-44 77-97 156-176 208-228
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010768|Gap junction alpha-1 protein (GJA1) ATGGGTGACTGGAGCGCCTTAGGCAAACTCCTTGACAAGGTTCAAGCCTACTCAACTGCT GGAGGGAAGGTGTGGCTGTCAGTACTTTTCATTTTCCGAATCCTGCTGCTGGGGACAGCG GTTGAGTCAGCCTGGGGAGATGAGCAGTCTGCCTTTCGTTGTAACACTCAGCAACCTGGT TGTGAAAATGTCTGCTATGACAAGTCTTTCCCAATCTCTCATGTGCGCTTCTGGGTCCTG CAGATCATATTTGTGTCTGTACCCACACTCTTGTACCTGGCTCATGTGTTCTATGTGATG CGAAAGGAAGAGAAACTGAACAAGAAAGAGGAAGAACTCAAGGTTGCCCAAACTGATGGT GTCAATGTGGACATGCACTTGAAGCAGATTGAGATAAAGAAGTTCAAGTACGGTATTGAA GAGCATGGTAAGGTGAAAATGCGAGGGGGGTTGCTGCGAACCTACATCATCAGTATCCTC TTCAAGTCTATCTTTGAGGTGGCCTTCTTGCTGATCCAGTGGTACATCTATGGATTCAGC TTGAGTGCTGTTTACACTTGCAAAAGAGATCCCTGCCCACATCAGGTGGACTGTTTCCTC TCTCGCCCCACGGAGAAAACCATCTTCATCATCTTCATGCTGGTGGTGTCCTTGGTGTCC CTGGCCTTGAATATCATTGAACTCTTCTATGTTTTCTTCAAGGGCGTTAAGGATCGGGTT AAGGGAAAGAGCGACCCTTACCATGCGACCAGTGGTGCGCTGAGCCCTGCCAAAGACTGT GGGTCTCAAAAATATGCTTATTTCAATGGCTGCTCCTCACCAACCGCTCCCCTCTCGCCT ATGTCTCCTCCTGGGTACAAGCTGGTTACTGGCGACAGAAACAATTCTTCTTGCCGCAAT TACAACAAGCAAGCAAGTGAGCAAAACTGGGCTAATTACAGTGCAGAACAAAATCGAATG GGGCAGGCGGGAAGCACCATCTCTAACTCCCATGCACAGCCTTTTGATTTCCCCGATGAT AACCAGAATTCTAAAAAACTAGCTGCTGGACATGAATTACAGCCACTAGCCATTGTGGAC CAGCGACCTTCAAGCAGAGCCAGCAGTCGTGCCAGCAGCAGACCTCGGCCTGATGACCTG GAGATCTAG
- Chromosome Location
- 6
- Locus
- 6q22.31
- External Identifiers
Resource Link UniProtKB ID P17302 UniProtKB Entry Name CXA1_HUMAN GenBank Protein ID 29917 GenBank Gene ID X52947 GeneCard ID GJA1 GenAtlas ID GJA1 HGNC ID HGNC:4274 PDB ID(s) 2LL2, 7F92, 7F93, 7F94, 7XQ9, 7XQB, 7XQD, 7XQF, 7XQG, 7XQH, 7XQI, 7XQJ, 7Z1T, 7Z22, 7Z23 KEGG ID hsa:2697 NCBI Gene ID 2697 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Carvedilol approved, investigational unknown target other Details Adenosine approved, investigational unknown transporter substrate Details Caprylic alcohol investigational yes target inhibitor Details