5'-nucleotidase

BE0001096ProteinHumansNT5E

Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084). It is acted on by 16 drugs in DrugBank.

Gene name
NT5E
UniProtKB entry
P21589Swiss-Prot
Cellular location
Cell membrane
Residues / weight
574 residues · 63,367 Da
Also known as
3.1.3.35 · 3.1.3.5 · 3.1.3.89 · 3.1.3.91 · 3.1.3.99

Resolves to

Protein
UniProtP21589UniProt name5NTD_HUMAN
Gene
HGNCHGNC:8021NCBI Gene4907GenBank23897GeneCardsNT5E
Pharmacology
IUPHAR/GtoPdb1232KEGGhsa:4907
Structure
PDB4H1SPDB4H1YPDB4H2B
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5'-nucleotidase, how selective are they, and which programs against it are still in active trials?

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