Tyrosine-protein kinase ITK/TSK

BE0001341ProteinHumansITK

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. It is acted on by 6 drugs in DrugBank.

Gene name
ITK
UniProtKB entry
Q08881Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
620 residues · 71,830 Da
Also known as
2.7.10.2 · EMT · IL-2-inducible T-cell kinase · Interleukin-2-inducible T-cell kinase · Kinase EMT

Resolves to

Protein
UniProtQ08881UniProt nameITK_HUMAN
Gene
HGNCHGNC:6171NCBI Gene3702GenBank399658GeneCardsITK
Pharmacology
IUPHAR/GtoPdb2046KEGGhsa:3702
Structure
PDB1SM2PDB1SNUPDB1SNX
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein kinase ITK/TSK, how selective are they, and which programs against it are still in active trials?

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