4-aminobutyrate aminotransferase GabT

BE0001510ProteinEscherichia coli (strain K12)gabT

Pyridoxal phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto acids. It is acted on by 2 drugs in DrugBank.

Gene name
gabT
UniProtKB entry
P22256Swiss-Prot
Residues / weight
426 residues · 45,774 Da
Also known as
(S)-3-amino-2-methylpropionate transaminase · 2.6.1.19 · 5-aminovalerate transaminase · GABA aminotransferase · GABA transaminase

Resolves to

Protein
UniProtP22256UniProt nameGABT_ECOLI
Gene
NCBI Gene948067GenBank147902
Pharmacology
KEGGecj:JW2637
Structure
PDB1SF2PDB1SFFPDB1SZK
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 4-aminobutyrate aminotransferase GabT, and which indications are they being tested in?

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