Alanine racemase, catabolic
Details
- Name
- Alanine racemase, catabolic
- Kind
- protein
- Synonyms
- 5.1.1.1
- Gene Name
- dadX
- UniProtKB Entry
- Q9HTQ2Swiss-Prot
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- NCBI Taxonomy ID
- 208964
- Amino acid sequence
>lcl|BSEQ0019181|Alanine racemase, catabolic MRPARALIDLQALRHNYRLAREATGARALAVIKADAYGHGAVRCAEALAAEADGFAVACI EEGLELREAGIRQPILLLEGFFEASELELIVAHDFWCVVHCAWQLEAIERASLARPLNVW LKMDSGMHRVGFFPEDFSAAHERLRASGKVAKIVMMSHFSRADELDCPRTEEQLAAFAAA SQGLEGEISLRNSPAVLGWPKVPSDWVRPGILLYGATPFERAHPLADRLRPVMTLESKVI SVRDLPAGEPVGYGARYSTERSQRIGVVAMGYADGYPRHAADGTLVFIDGKPGRLVGRVS MDMLTVDLTDHPQAGLGSRVELWGPNVPVGALAAQFGSIPYQLLCNLKRVPRVYSGA
- Number of residues
- 357
- Molecular Weight
- 38914.32
- Theoretical pI
- 6.85
- GO Classification
- Functionsalanine racemase activity / pyridoxal phosphate bindingProcessesalanine metabolic process
- General Function
- Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.
- Specific Function
- alanine racemase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019182|Alanine racemase, catabolic (dadX) ATGCGCCCCGCCCGTGCCCTGATCGACCTGCAAGCCCTTCGTCACAACTATCGGCTGGCC CGCGAGGCCACCGGCGCCCGTGCGCTCGCGGTGATCAAGGCGGACGCATACGGCCACGGC GCGGTGCGCTGTGCCGAAGCGCTGGCGGCCGAGGCCGATGGCTTCGCCGTGGCCTGCATC GAGGAGGGCCTGGAGCTGCGCGAGGCCGGTATCCGCCAGCCGATCCTGCTGCTGGAGGGC TTCTTCGAGGCGTCCGAGCTGGAGCTGATCGTCGCCCACGACTTCTGGTGCGTGGTGCAT TGCGCCTGGCAATTGGAGGCGATCGAACGCGCCAGCCTGGCCCGCCCGCTGAACGTCTGG CTGAAGATGGATTCGGGCATGCACCGCGTCGGCTTCTTCCCCGAGGACTTCAGCGCCGCC CACGAGCGCCTGCGGGCCAGCGGCAAGGTGGCGAAGATCGTGATGATGAGTCACTTCTCC CGCGCCGACGAACTGGATTGCCCGCGCACCGAGGAACAGCTCGCCGCCTTCGCGGCCGCG AGCCAGGGCCTGGAAGGCGAGATCAGCCTGCGCAATTCGCCAGCCGTGCTCGGCTGGCCG AAGGTGCCCAGCGATTGGGTACGTCCGGGCATCCTGCTCTACGGAGCCACGCCGTTCGAG CGCGCACATCCGCTGGCCGACCGCTTGCGCCCGGTGATGACCCTAGAATCGAAGGTGATC AGCGTCCGCGACCTGCCGGCCGGCGAACCGGTCGGCTACGGCGCGCGCTACAGCACCGAG CGTAGCCAGCGCATCGGCGTGGTCGCCATGGGCTACGCCGATGGCTATCCGCGCCACGCC GCCGACGGCACCCTTGTGTTCATCGACGGCAAGCCGGGGCGCCTGGTTGGCCGGGTATCG ATGGACATGCTCACCGTCGACCTTACCGACCATCCCCAGGCCGGGCTGGGCAGCCGGGTC GAACTATGGGGCCCGAACGTGCCGGTCGGCGCCCTGGCGGCGCAGTTCGGCAGCATTCCC TACCAGCTGCTGTGCAACCTGAAAAGGGTGCCGCGCGTCTATTCCGGGGCTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9HTQ2 UniProtKB Entry Name ALR2_PSEAE GenBank Protein ID 5690425 GenBank Gene ID AF165881 PDB ID(s) 1RCQ KEGG ID pae:PA5302 NCBI Gene ID 878055 - General References
- Strych U, Huang HC, Krause KL, Benedik MJ: Characterization of the alanine racemases from Pseudomonas aeruginosa PAO1. Curr Microbiol. 2000 Oct;41(4):290-4. [Article]
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- LeMagueres P, Im H, Dvorak A, Strych U, Benedik M, Krause KL: Crystal structure at 1.45 A resolution of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms. Biochemistry. 2003 Dec 23;42(50):14752-61. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-Lysine experimental unknown target Details Lysine Nz-Carboxylic Acid experimental unknown target Details