Cyclin-dependent kinase 7

BE0001913ProteinHumansCDK7

Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription (PubMed:9852112, PubMed:19136461, PubMed:26257281, PubMed:28768201). It is acted on by 10 drugs in DrugBank.

Gene name
CDK7
UniProtKB entry
P50613Swiss-Prot
Cellular location
Nucleus
Residues / weight
346 residues · 39,038 Da
Also known as
2.7.11.22 · 2.7.11.23 · 39 kDa protein kinase · CAK · CAK1

Resolves to

Protein
UniProtP50613UniProt nameCDK7_HUMAN
Gene
HGNCHGNC:1778NCBI Gene1022GenBank485909GeneCardsCDK7
Pharmacology
IUPHAR/GtoPdb1979KEGGhsa:1022
Structure
PDB1UA2PDB6O9LPDB6XBZ
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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75+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 7, how selective are they, and which programs against it are still in active trials?

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