Dihydrofolate reductase

BE0002010ProteinEscherichia coli (strain K12)folA

Key enzyme in folate metabolism. It is acted on by 9 drugs in DrugBank.

Gene name
folA
UniProtKB entry
P0ABQ4Swiss-Prot
Residues / weight
159 residues · 17,999 Da
Also known as
1.5.1.3 · tmrA

Resolves to

Protein
UniProtP0ABQ4UniProt nameDYR_ECOLI
Gene
NCBI Gene944790GenBank146006
Pharmacology
KEGGecj:JW0047
Structure
PDB1DDRPDB1DDSPDB1DHI
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dihydrofolate reductase, how selective are they, and which programs against it are still in active trials?

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