Sodium channel protein type 2 subunit alpha

BE0002081ProteinHumansSCN2A

Mediates the voltage-dependent sodium ion permeability of excitable membranes. It is acted on by 9 drugs in DrugBank.

Gene name
SCN2A
UniProtKB entry
Q99250Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,005 residues · 227,973 Da
Also known as
HBA · HBSC II · NAC2 · SCN2A1 · SCN2A2

Resolves to

Protein
UniProtQ99250UniProt nameSCN2A_HUMAN
Gene
HGNCHGNC:10588NCBI Gene6326GenBank457879GeneCardsSCN2A
Pharmacology
IUPHAR/GtoPdb579KEGGhsa:6326
Structure
PDB2KAVPDB4JPZPDB4RLY
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel protein type 2 subunit alpha, how selective are they, and which programs against it are still in active trials?

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