Sodium channel protein type 4 subunit alpha

BE0002083ProteinHumansSCN4A

Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. It is acted on by 12 drugs in DrugBank.

Gene name
SCN4A
UniProtKB entry
P35499Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,836 residues · 208,059 Da
Also known as
SkM1 · Sodium channel protein skeletal muscle subunit alpha · Sodium channel protein type IV subunit alpha · Voltage-gated sodium channel subunit alpha Nav1.4

Resolves to

Protein
UniProtP35499UniProt nameSCN4A_HUMAN
Gene
HGNCHGNC:10591NCBI Gene6329GenBank338213GeneCardsSCN4A
Pharmacology
IUPHAR/GtoPdb581KEGGhsa:6329
Structure
PDB6AGFPDB6MBAPDB6MC9
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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73+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel protein type 4 subunit alpha, how selective are they, and which programs against it are still in active trials?

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