Low affinity immunoglobulin gamma Fc region receptor III-A

BE0002097ProteinHumansFCGR3A

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). It is acted on by 25 drugs in DrugBank.

Gene name
FCGR3A
UniProtKB entry
P08637Swiss-Prot
Cellular location
Cell membrane
Residues / weight
254 residues · 29,089 Da
Also known as
CD16-II · CD16A · CD16a antigen · Fc-gamma RIII · Fc-gamma RIII-alpha

Resolves to

Protein
UniProtP08637UniProt nameFCG3A_HUMAN
Gene
HGNCHGNC:3619NCBI Gene2214GenBank31324GeneCardsFCGR3A
Pharmacology
IUPHAR/GtoPdb3017KEGGhsa:2214
Structure
PDB3AY4PDB3SGJPDB3SGK
Drugs

What you can answer from here — as of September 07, 2019

25DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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57+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Low affinity immunoglobulin gamma Fc region receptor III-A, how selective are they, and which programs against it are still in active trials?

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