Phytanoyl-CoA dioxygenase, peroxisomal

BE0002117ProteinHumansPHYH

Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA... It is acted on by 4 drugs in DrugBank.

Gene name
PHYH
UniProtKB entry
O14832Swiss-Prot
Cellular location
Peroxisome
Residues / weight
338 residues · 38,538 Da
Also known as
1.14.11.18 · PAHX · PhyH · Phytanic acid oxidase · Phytanoyl-CoA alpha-hydroxylase

Resolves to

Protein
UniProtO14832UniProt namePAHX_HUMAN
Gene
HGNCHGNC:8940NCBI Gene5264GenBank2564671GeneCardsPHYH
Pharmacology
KEGGhsa:5264
Structure
PDB2A1X
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phytanoyl-CoA dioxygenase, peroxisomal, how selective are they, and which programs against it are still in active trials?

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