Asialoglycoprotein receptor 2

BE0002118ProteinHumansASGR2

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It is acted on by 4 drugs in DrugBank.

Gene name
ASGR2
UniProtKB entry
P07307Swiss-Prot
Cellular location
Membrane
Residues / weight
311 residues · 35,092 Da
Also known as
ASGP-R 2 · ASGPR 2 · C-type lectin domain family 4 member H2 · CLEC4H2 · Hepatic lectin H2

Resolves to

Protein
UniProtP07307UniProt nameASGR2_HUMAN
Gene
HGNCHGNC:743NCBI Gene433GenBank179081GeneCardsASGR2
Pharmacology
KEGGhsa:433
Structure
PDB8URF
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Asialoglycoprotein receptor 2, how selective are they, and which programs against it are still in active trials?

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