Fibroblast growth factor receptor 1

BE0002131ProteinHumansFGFR1

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. It is acted on by 45 drugs in DrugBank.

Gene name
FGFR1
UniProtKB entry
P11362Swiss-Prot
Cellular location
Cell membrane
Residues / weight
822 residues · 91,867 Da
Also known as
2.7.10.1 · Basic fibroblast growth factor receptor 1 · bFGF-R-1 · BFGFR · CEK

Resolves to

Protein
UniProtP11362UniProt nameFGFR1_HUMAN
Gene
HGNCHGNC:3688NCBI Gene2260GenBank31368GeneCardsFGFR1
Pharmacology
IUPHAR/GtoPdb1808KEGGhsa:2260
Structure
PDB1AGWPDB1CVSPDB1EVT
Drugs

What you can answer from here — as of September 07, 2019

45DrugsApproved to experimental, with action, bond type and pharmacological action
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23Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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202+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fibroblast growth factor receptor 1, how selective are they, and which programs against it are still in active trials?

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