Aromatic-L-amino-acid decarboxylase

BE0002151ProteinHumansDDC

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin. It is acted on by 16 drugs in DrugBank.

Gene name
DDC
UniProtKB entry
P20711Swiss-Prot
Residues / weight
480 residues · 53,926 Da
Also known as
4.1.1.28 · AADC · DDC · DOPA decarboxylase

Resolves to

Protein
UniProtP20711UniProt nameDDC_HUMAN
Gene
HGNCHGNC:2719NCBI Gene1644GenBank181521GeneCardsDDC
Pharmacology
KEGGhsa:1644
Structure
PDB3RBFPDB3RBLPDB3RCH
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aromatic-L-amino-acid decarboxylase, how selective are they, and which programs against it are still in active trials?

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