G protein-activated inward rectifier potassium channel 4

BE0002218ProteinHumansKCNJ5

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. It is acted on by 4 drugs in DrugBank.

Gene name
KCNJ5
UniProtKB entry
P48544Swiss-Prot
Cellular location
Membrane
Residues / weight
419 residues · 47,667 Da
Also known as
Cardiac inward rectifier · CIR · GIRK-4 · GIRK4 · Heart KATP channel

Resolves to

Protein
UniProtP48544UniProt nameKCNJ5_HUMAN
Gene
HGNCHGNC:6266NCBI Gene3762GenBank1055026GeneCardsKCNJ5
Pharmacology
IUPHAR/GtoPdb437KEGGhsa:3762
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on G protein-activated inward rectifier potassium channel 4, how selective are they, and which programs against it are still in active trials?

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