Phorbol 12-myristate 13-acetate diester

DB17045InvestigationalSmall molecule

Phorbol 12-myristate 13-acetate diester is an inducer of neutrophil extracellular traps (NETs).

Chemical structure of Phorbol 12-myristate 13-acetate diester
Formula / weight
C36H56O8 · 616.836 g/mol (avg)
Also known as
12-o-tetradecanoylphorbol-13-acetate · 12-tetradecanoylphorbol 13-acetate · Phorbol 12-myristate 13-acetate · Phorbol myristate acetate · Pma (phorbol ester)
Code names
NSC-262244 · PMA

Resolves to

Compound
UNIINI40JAQ945CAS16561-29-8ChEMBLCHEMBL279115ChEBI37537KEGGC05151
Structure
InChIKeyPHEDXBVPIONUQT-RGYGYFBISA-NSMILES[H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCCCCCCCCCCCC)[C@@]1(OC(C)=O)C2(C)C
Targets
P48544KCNJ5Q5JUK3KCNT1Q9HBA0TRPV4Q6UVM3KCNT2

What you can answer from here — as of April 23, 2025

4Protein targetsEach mapped to UniProt, with action and pharmacological action
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2Clinical trialsPhase, status and sponsor resolved per trial
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5+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Phorbol 12-myristate 13-acetate diester, and which of those have an active Phase 3 trial?

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