Voltage-dependent N-type calcium channel subunit alpha-1B

BE0002226ProteinHumansCACNA1B

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell... It is acted on by 20 drugs in DrugBank.

Gene name
CACNA1B
UniProtKB entry
Q00975Swiss-Prot
Cellular location
Membrane
Residues / weight
2,339 residues · 262,494 Da
Also known as
BIII · Brain calcium channel III · CACH5 · CACNL1A5 · Calcium channel, L type, alpha-1 polypeptide isoform 5

Resolves to

Protein
UniProtQ00975UniProt nameCAC1B_HUMAN
Gene
HGNCHGNC:1389NCBI Gene774GenBank179758GeneCardsCACNA1B
Pharmacology
IUPHAR/GtoPdb533KEGGhsa:774
Structure
PDB2LCMPDB7MIXPDB7MIY
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent N-type calcium channel subunit alpha-1B, how selective are they, and which programs against it are still in active trials?

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