Benidipine is a synthetic dihydropyridine calcium channel blocker used to treat hypertension and angina pectoris. Benidipine has the formula 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester hydrochloride.
- Mechanism
- Curator reviewed · 2 references
Benidipine is a tripe calcium channel inhibitor by inhibiting L, N and T type calcium channel. It presents a very long-lasting activity that can be explained by its high affinity for cell membranes from the DHP binding site; this characteristic indicated a long-lasting pharmacological activity of benidipine. The additional property of benidipine is the vascular selectivity towards peripheral blood vessels.
- Primary indication
- Benidipine is a potent and long-lasting drug indicated for the treatment of cardiovascular diseases such as hypertension, renoparenchymal hypertension and angina pectoris.Curator reviewed · 6 structured indications
- Formula / weight
- C28H31N3O6 · 505.571 g/mol (avg)
Resolves to
QZVNQOLPLYWLHQ-ZEQKJWHPSA-NSMILESCOC(=O)C1=C(C)NC(C)=C([C@@H]1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)O[C@@H]1CCCN(CC2=CC=CC=C2)C1What you can answer from here — as of August 30, 2026
Which drugs share a target with Benidipine, and which of those have an active Phase 3 trial?
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