Glutathione S-transferase A1

BE0002281ProteinHumansGSTA1

Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). It is acted on by 14 drugs in DrugBank.

Gene name
GSTA1
UniProtKB entry
P08263Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
222 residues · 25,631 Da
Also known as
13-hydroperoxyoctadecadienoate peroxidase · 2.5.1.18 · Androst-5-ene-3,17-dione isomerase · GST class-alpha member 1 · GST HA subunit 1

Resolves to

Protein
UniProtP08263UniProt nameGSTA1_HUMAN
Gene
HGNCHGNC:4626NCBI Gene2938GenBank306809GeneCardsGSTA1
Pharmacology
KEGGhsa:2938
Structure
PDB1GSDPDB1GSEPDB1GSF
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione S-transferase A1, how selective are they, and which programs against it are still in active trials?

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