Histone deacetylase 3

BE0002367ProteinHumansHDAC3

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates (PubMed:21030595, PubMed:21444723, PubMed:23911289, PubMed:25301942, PubMed:28167758, PubMed:28497810, PubMed:32404892, PubMed:22230954). It is acted on by 6 drugs in DrugBank.

Gene name
HDAC3
UniProtKB entry
O15379Swiss-Prot
Cellular location
Nucleus
Residues / weight
428 residues · 48,847 Da
Also known as
3.5.1.98 · HD3 · Protein deacetylase HDAC3 · Protein deacylase HDAC3 · RPD3-2

Resolves to

Protein
UniProtO15379UniProt nameHDAC3_HUMAN
Gene
HGNCHGNC:4854NCBI Gene8841GenBank2326173GeneCardsHDAC3
Pharmacology
IUPHAR/GtoPdb2617KEGGhsa:8841
Structure
PDB4A69
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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25GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone deacetylase 3, how selective are they, and which programs against it are still in active trials?

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