RNA-dependent RNA-polymerase

Details

Name
RNA-dependent RNA-polymerase
Kind
protein
Synonyms
Not Available
Gene Name
NS5b
UniProtKB Entry
O39930TrEMBL
Organism
Hepatitis C Virus
NCBI Taxonomy ID
11103
Amino acid sequence
>lcl|BSEQ0011720|RNA-dependent RNA-polymerase
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIR
SVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGSSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVCGDDLVVICESAGTQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIP
AASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
Number of residues
591
Molecular Weight
65753.05
Theoretical pI
9.02
GO Classification
Functions
nucleotide binding / RNA binding / RNA-directed RNA polymerase activity
Processes
viral RNA genome replication
Components
integral component of membrane
General Function
Not Available
Specific Function
ATP hydrolysis activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
571-588
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0004719|1776 bp
TCGATGTCCTACACATGGACAGGCGCCCTGATCACGCCATGCGCTGCGGAGGAATCCAAG
CTGCCCATCAATGCACTGAGCAACTCTTTGCTCCGTCACCACAACATGGTCTATGCTACA
ACATCTCGCAGCGCAAGCCTGCGGCAGAAGAAGGTCACCTTTGACAGACTGCAGGTCCTG
GACGACCACTACCGGGACGTGCTCAAGGAGATGAAGGCGAAGGCGTCCACAGTTAAGGCT
AAACTTCTATCCGTGGAGGAAGCCTGTAAGCTGACGCCCCCACATTCGGCCAAATCTAAA
TTTGGCTATGGGGCAAAGGACGTCCGGAACCTATCCAGCAAGGCCGTTAACCACATCCGC
TCCGTGTGGAAGGACTTGCTGGAAGACACTGAGACACCAATTGACACCACCATCATGGCA
AAAAATGAGGTTTTCTGCGTCCAACCAGAGAAGGGGGGCCGCAAGCCAGCTCGCCTTATC
GTATTCCCAGATTTGGGGGTTCGTGTGTGCGAGAAAATGGCCCTTTACGATGTGGTCTCC
ACCCTCCCTCAGGCCGTGATGGGCTCTTCATACGGATTCCAGTACTCTCCTGGACAGCGG
GTCGAGTTCCTGGTGAATACCTGGAAATCGAAAAAATGCCCTATGGGCTTCTCATATGAC
ACCCGCTGCTTTGACTCAACGGTCACTGAGAATGACATCCGTGTTGAGGAGTCAATCTAC
CAATGTTGTGACTTGGCCCCCGAAGCCAGACAGGCCATAAGGTCGCTCACAGAGCGGCTT
TACATCGGGGGCCCCCTGACTAATTCAAAGGGGCAGAACTGCGGCTATCGCCGGTGCCGC
GCGAGCGGTGTACTGACGACCAGCTGCGGTAATACCCTCACATGTTACTTGAAGGCCTCT
GCGGCCTGTCGAGCTGCGAAGCTCCAGGACTGCACGATGCTCGTGTGCGGAGACGACCTT
GTCGTTATCTGTGAAAGCGCGGGGACCCAAGAGGACGCGGCGAGCCTACGAGCCTTCACG
GAGGCTATGACTAGATACTCTGCCCCCCCTGGGGACCCGCCCCAACCAGAATACGACTTG
GAGTTGATAACATCATGCTCCTCCAATGTGTCTGTCGCGCACGATGCATCTGGCAAAAGG
GTGTACTATCTCACCCGTGACCCCACCACCCCCCTTGCGCGGGCTGCGTGGGAGACAGCT
AGACACACTCCAGTCAATTCCTGGCTAGGCAACATCATCATGTATGCGCCCACCTTGTGG
GCAAGGATGATCCTGATGACTCATTTCTTCTCCATCCTTCTAGCTCAGGAACAACTTGAA
AAAGCCCTAGATTGTCAGATCTACGGGGCCTGTTACTCCATTGAGCCACTTGACCTACCT
CAGATCATTCAACGACTCCATGGCCTTAGCGCATTTTCACTCCATAGTTACTCTCCAGGT
GAGATCAATAGGGTGGCTTCATGCCTCAGGAAACTTGGGGTACCGCCCTTGCGAGTCTGG
AGACATCGGGCCAGAAGTGTCCGCGCTAGGCTACTGTCCCAGGGGGGGAGGGCTGCCACT
TGTGGCAAGTACCTCTTCAACTGGGCAGTAAGGACCAAGCTCAAACTCACTCCAATCCCG
GCTGCGTCCCAGTTGGATTTATCCAGCTGGTTCGTTGCTGGTTACAGCGGGGGAGACATA
TATCACAGCCTGTCTCGTGCCCGACCCCGCTGGTTCATGTGGTGCCTACTCCTACTTTCT
GTAGGGGTAGGCATCTACCTGCTCCCCAACCGGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO39930
UniProtKB Entry NameO39930_9HEPC
GenBank Gene IDZ97730
General References
  1. Lohmann V, Korner F, Herian U, Bartenschlager R: Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol. 1997 Nov;71(11):8416-28. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
R1626investigationalunknowntargetDetails
(2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACIDexperimentalunknowntargetDetails
(2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACIDexperimentalunknowntargetDetails
SofosbuvirapprovedyestargetinhibitorDetails