Epithelial cell adhesion molecule

BE0002446ProteinHumansEPCAM

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. It is acted on by 12 drugs in DrugBank.

Gene name
EPCAM
UniProtKB entry
P16422Swiss-Prot
Cellular location
Lateral cell membrane
Residues / weight
314 residues · 34,932 Da
Also known as
Adenocarcinoma-associated antigen · Cell surface glycoprotein Trop-1 · EGP · EGP314 · Ep-CAM

Resolves to

Protein
UniProtP16422UniProt nameEPCAM_HUMAN
Gene
HGNCHGNC:11529NCBI Gene4072GeneCardsEPCAM
Pharmacology
KEGGhsa:4072
Structure
PDB4MZVPDB6I07
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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13Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Epithelial cell adhesion molecule, how selective are they, and which programs against it are still in active trials?

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