Protein disulfide-isomerase

BE0002467ProteinHumansP4HB

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. It is acted on by 12 drugs in DrugBank.

Gene name
P4HB
UniProtKB entry
P07237Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
508 residues · 57,116 Da
Also known as
5.3.4.1 · Cellular thyroid hormone-binding protein · ERBA2L · p55 · PDI

Resolves to

Protein
UniProtP07237UniProt namePDIA1_HUMAN
Gene
HGNCHGNC:8548NCBI Gene5034GeneCardsP4HB
Pharmacology
KEGGhsa:5034
Structure
PDB1BJXPDB1MEKPDB1X5C
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein disulfide-isomerase, how selective are they, and which programs against it are still in active trials?

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