Probable ATP-dependent RNA helicase DDX6

BE0002501ProteinHumansDDX6

Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). It is acted on by 1 drug in DrugBank.

Gene name
DDX6
UniProtKB entry
P26196Swiss-Prot
Cellular location
Cytoplasm, P-body
Residues / weight
483 residues · 54,416 Da
Also known as
3.6.4.13 · ATP-dependent RNA helicase p54 · DEAD box protein 6 · HLR2 · Oncogene RCK

Resolves to

Protein
UniProtP26196UniProt nameDDX6_HUMAN
Gene
HGNCHGNC:2747NCBI Gene1656GeneCardsDDX6
Pharmacology
KEGGhsa:1656
Structure
PDB1VECPDB2WAXPDB2WAY
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Probable ATP-dependent RNA helicase DDX6, and which indications are they being tested in?

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