Probable ATP-dependent RNA helicase DDX6

Details

Name
Probable ATP-dependent RNA helicase DDX6
Kind
protein
Synonyms
  • 3.6.4.13
  • ATP-dependent RNA helicase p54
  • DEAD box protein 6
  • HLR2
  • Oncogene RCK
  • RCK
Gene Name
DDX6
UniProtKB Entry
P26196Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0016809|Probable ATP-dependent RNA helicase DDX6
MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ
SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS
PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV
SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV
QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL
MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS
CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH
RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED
EKP
Number of residues
483
Molecular Weight
54416.42
Theoretical pI
8.93
GO Classification
Functions
ATP hydrolysis activity / cadherin binding / mRNA binding / RNA binding
Processes
miRNA-mediated gene silencing by inhibition of translation / negative regulation of translation / neuron differentiation / P-body assembly / stress granule assembly
Components
cytoplasmic ribonucleoprotein granule / nucleus / P-body
General Function
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573)
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm, P-body
Gene sequence
>lcl|BSEQ0016810|Probable ATP-dependent RNA helicase DDX6 (DDX6)
ATGAGCACGGCCAGAACAGAGAACCCTGTTATAATGGGTCTGTCCAGTCAAAATGGTCAG
CTGAGAGGCCCTGTGAAACCCACTGGTGGCCCTGGAGGAGGGGGCACACAGACACAGCAA
CAGATGAACCAGCTGAAAAACACCAACACAATCAATAATGGCACTCAGCAGCAAGCACAG
AGTATGACCACCACTATTAAACCTGGTGATGACTGGAAAAAGACTTTAAAACTCCCTCCA
AAGGATCTAAGAATCAAAACTTCGGATGTGACCTCCACAAAAGGAAATGAGTTTGAAGAT
TACTGTTTGAAACGGGAGTTACTGATGGGAATTTTTGAAATGGGCTGGGAAAAGCCATCT
CCTATTCAGGAGGAGAGCATTCCCATTGCTTTATCTGGTAGGGATATCTTAGCTAGAGCA
AAAAATGGAACAGGCAAGAGCGGTGCCTACCTCATTCCCTTACTTGAACGGCTAGACCTG
AAGAAGGACAATATACAAGCAATGGTGATTGTTCCCACTAGAGAACTTGCTCTACAGGTC
AGTCAAATTTGCATCCAGGTCAGCAAACACATGGGAGGGGCCAAAGTGATGGCAACCACA
GGAGGAACCAATTTACGAGATGACATAATGAGGCTTGATGATACAGTGCACGTGGTGATT
GCTACCCCTGGGAGAATCCTGGATCTTATTAAGAAAGGAGTAGCAAAGGTTGATCATGTC
CAGATGATAGTATTGGATGAGGCAGATAAGTTGCTGTCACAGGATTTTGTGCAGATAATG
GAGGATATTATTCTCACGCTACCTAAAAACAGGCAGATTTTACTATATTCCGCTACTTTC
CCTCTTAGTGTACAGAAGTTCATGAATTCCCATTTGCAGAAACCCTATGAGATTAACCTG
ATGGAGGAACTAACTCTGAAGGGAGTAACCCAGTACTACGCATATGTAACTGAGCGCCAA
AAAGTACACTGCCTCAACACACTTTTCTCCAGGCTTCAGATAAACCAGTCGATCATTTTC
TGTAACTCCTCTCAGCGAGTTGAATTGCTAGCCAAGAAGATTTCTCAACTGGGTTATTCT
TGCTTCTATATTCATGCTAAAATGAGGCAGGAACATCGAAATCGTGTATTTCATGATTTC
CGAAATGGCTTATGCCGCAATCTTGTTTGCACTGATCTGTTTACCCGAGGTATTGATATA
CAAGCTGTGAATGTGGTAATAAACTTTGATTTCCCAAAGCTGGCAGAGACCTATCTCCAT
CGTATTGGAAGATCAGGTCGCTTTGGTCATCTTGGCTTAGCCATCAACTTGATCACATAT
GATGATCGCTTCAACCTGAAAAGTATTGAGGAGCAGCTGGGAACAGAAATTAAACCTATT
CCGAGCAACATTGATAAGAGCCTGTATGTGGCAGAATACCACAGCGAGCCTGTAGAAGAT
GAGAAACCTTAA
Chromosome Location
11
Locus
11q23.3
External Identifiers
ResourceLink
UniProtKB IDP26196
UniProtKB Entry NameDDX6_HUMAN
GenBank Gene IDBC065007
GeneCard IDDDX6
GenAtlas IDDDX6
HGNC IDHGNC:2747
PDB ID(s)1VEC, 2WAX, 2WAY, 4CRW, 4CT4, 4CT5, 5ANR, 6F9S, 6S8S
KEGG IDhsa:1656
NCBI Gene ID1656
General References
  1. Lu D, Yunis JJ: Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. Nucleic Acids Res. 1992 Apr 25;20(8):1967-72. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Akao Y, Seto M, Yamamoto K, Iida S, Nakazawa S, Inazawa J, Abe T, Takahashi T, Ueda R: The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. Cancer Res. 1992 Nov 1;52(21):6083-7. [Article]
  4. Fenger-Gron M, Fillman C, Norrild B, Lykke-Andersen J: Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell. 2005 Dec 22;20(6):905-15. [Article]
  5. Wichroski MJ, Robb GB, Rana TM: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog. 2006 May;2(5):e41. Epub 2006 May 12. [Article]
  6. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6. [Article]
  7. James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12499-504. doi: 10.1073/pnas.0914987107. Epub 2010 Jun 28. [Article]
  8. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  9. Phalora PK, Sherer NM, Wolinsky SM, Swanson CM, Malim MH: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. J Virol. 2012 Nov;86(21):11712-24. doi: 10.1128/JVI.00595-12. Epub 2012 Aug 22. [Article]
  10. Kaehler C, Isensee J, Nonhoff U, Terrey M, Hucho T, Lehrach H, Krobitsch S: Ataxin-2-like is a regulator of stress granules and processing bodies. PLoS One. 2012;7(11):e50134. doi: 10.1371/journal.pone.0050134. Epub 2012 Nov 27. [Article]
  11. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  12. Matsui T, Hogetsu K, Akao Y, Tanaka M, Sato T, Kumasaka T, Tanaka N: Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54. Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):156-9. Epub 2003 Dec 18. [Article]
  13. Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E, Weichenrieder O: Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Mol Cell. 2009 Mar 13;33(5):661-8. doi: 10.1016/j.molcel.2009.02.014. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
D-tartaric acidexperimentalunknowntargetDetails