Apolipoprotein A-I

BE0003449ProteinHumansAPOA1

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). It is acted on by 11 drugs in DrugBank.

Gene name
APOA1
UniProtKB entry
P02647Swiss-Prot
Cellular location
Secreted
Residues / weight
267 residues · 30,778 Da
Also known as
Apo-AI · ApoA-I · Apolipoprotein A1

Resolves to

Protein
UniProtP02647UniProt nameAPOA1_HUMAN
Gene
HGNCHGNC:600NCBI Gene335GeneCardsAPOA1
Pharmacology
KEGGhsa:335
Structure
PDB1AV1PDB1GW3PDB1GW4
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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70+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Apolipoprotein A-I, how selective are they, and which programs against it are still in active trials?

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