T-cell surface glycoprotein CD3 delta chain

BE0003456ProteinHumansCD3D

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. It is acted on by 3 drugs in DrugBank.

Gene name
CD3D
UniProtKB entry
P04234Swiss-Prot
Cellular location
Cell membrane
Residues / weight
171 residues · 18,929 Da
Also known as
T-cell receptor T3 delta chain · T3D

Resolves to

Protein
UniProtP04234UniProt nameCD3D_HUMAN
Gene
HGNCHGNC:1673NCBI Gene915GeneCardsCD3D
Pharmacology
KEGGhsa:915
Structure
PDB1XIWPDB6JXRPDB7FJD
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-cell surface glycoprotein CD3 delta chain, how selective are they, and which programs against it are still in active trials?

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