Cholesterol side-chain cleavage enzyme, mitochondrial

BE0003537ProteinHumansCYP11A1

A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:21636783). It is acted on by 14 drugs in DrugBank.

Gene name
CYP11A1
UniProtKB entry
P05108Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
521 residues · 60,102 Da
Also known as
1.14.15.6 · Cholesterol desmolase · CYP11A · CYPXIA1 · Cytochrome P450 11A1

Resolves to

Protein
UniProtP05108UniProt nameCP11A_HUMAN
Gene
HGNCHGNC:2590NCBI Gene1583GenBank181376GeneCardsCYP11A1
Pharmacology
IUPHAR/GtoPdb1358KEGGhsa:1583
Structure
PDB3N9YPDB3N9ZPDB3NA0
Drugs

What you can answer from here — as of September 07, 2019

14DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cholesterol side-chain cleavage enzyme, mitochondrial, how selective are they, and which programs against it are still in active trials?

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