Adenosine kinase

BE0003540ProteinHumansADK

Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines (PubMed:21963049, PubMed:40840445, PubMed:6246102, PubMed:8577746, PubMed:9070863). It is acted on by 10 drugs in DrugBank.

Gene name
ADK
UniProtKB entry
P55263Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
362 residues · 40,545 Da
Also known as
2.7.1.20 · Adenosine 5'-phosphotransferase · AK · N6-isopentenyladenosine kinase · N6-methyladenosine kinase

Resolves to

Protein
UniProtP55263UniProt nameADK_HUMAN
Gene
HGNCHGNC:257NCBI Gene132GenBank1224125GeneCardsADK
Pharmacology
IUPHAR/GtoPdb1231KEGGhsa:132
Structure
PDB1BX4PDB2I6APDB2I6B
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenosine kinase, how selective are they, and which programs against it are still in active trials?

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