Cytochrome P450 11B2, mitochondrial

BE0003542ProteinHumansCYP11B2

A cytochrome P450 monooxygenase that catalyzes the biosynthesis of aldosterone, the main mineralocorticoid in the human body responsible for salt and water homeostasis, thus involved in blood pressure regulation, arterial hypertension, and the development of... It is acted on by 20 drugs in DrugBank.

Gene name
CYP11B2
UniProtKB entry
P19099Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
503 residues · 57,560 Da
Also known as
ALDOS · Aldosterone synthase · Aldosterone-synthesizing enzyme · Corticosterone 18-monooxygenase, CYP11B2 · CYPXIB2

Resolves to

Protein
UniProtP19099UniProt nameC11B2_HUMAN
Gene
HGNCHGNC:2592NCBI Gene1585GenBank35200GeneCardsCYP11B2
Pharmacology
IUPHAR/GtoPdb1360KEGGhsa:1585
Structure
PDB4DVQPDB4FDHPDB4ZGX
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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54+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 11B2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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