Guanylate cyclase soluble subunit alpha-2

BE0003578ProteinHumansGUCY1A2

Alpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. It is acted on by 7 drugs in DrugBank.

Gene name
GUCY1A2
UniProtKB entry
P33402Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
732 residues · 81,749 Da
Also known as
4.6.1.2 · GCS-alpha-2 · GUC1A2 · GUCSA2

Resolves to

Protein
UniProtP33402UniProt nameGCYA2_HUMAN
Gene
HGNCHGNC:4684NCBI Gene2977GenBank31671GeneCardsGUCY1A2
Pharmacology
KEGGhsa:2977
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guanylate cyclase soluble subunit alpha-2, how selective are they, and which programs against it are still in active trials?

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