Potassium channel subfamily K member 3

BE0003582ProteinHumansKCNK3

K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. It is acted on by 7 drugs in DrugBank.

Gene name
KCNK3
UniProtKB entry
O14649Swiss-Prot
Cellular location
Cell membrane
Residues / weight
394 residues · 43,518 Da
Also known as
Acid-sensitive potassium channel protein TASK-1 · TASK · TASK1 · TWIK-related acid-sensitive K(+) channel 1 · Two pore K(+) channel KT3.1

Resolves to

Protein
UniProtO14649UniProt nameKCNK3_HUMAN
Gene
HGNCHGNC:6278NCBI Gene3777GenBank2465542GeneCardsKCNK3
Pharmacology
IUPHAR/GtoPdb515KEGGhsa:3777
Structure
PDB6RV2PDB6RV3PDB6RV4
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium channel subfamily K member 3, how selective are they, and which programs against it are still in active trials?

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