Neuronal acetylcholine receptor subunit beta-4

BE0003584ProteinHumansCHRNB4

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 8 drugs in DrugBank.

Gene name
CHRNB4
UniProtKB entry
P30926Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
498 residues · 56,379 Da

Resolves to

Protein
UniProtP30926UniProt nameACHB4_HUMAN
Gene
HGNCHGNC:1964NCBI Gene1143GenBank1458126GeneCardsCHRNB4
Pharmacology
KEGGhsa:1143
Structure
PDB6PV7PDB6PV8PDB8ZRN
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuronal acetylcholine receptor subunit beta-4, how selective are they, and which programs against it are still in active trials?

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