Pentolinium

DB01090ApprovedSmall molecule

Pentolinium is a nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.

Mechanism: Pentolinium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
Curator reviewed
Primary indication: Used to produce controlled hypotension during surgical procedures and in hypertensive crises.Curator reviewed
Formula / weight: C₁₅H₃₂N₂ · 240.428 g/mol (avg)
Also known as: Pentolineum · Pentolonium · Pentolonum

Resolves to

Compound

Clinical / RWD

Structure

InChIKeyXSBSKEQEUFOSDD-UHFFFAOYSA-NSMILESC[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1

Targets

What you can answer from here — as of September 16, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,054Drug interactionsStructured to mechanism, not free text

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Pentolinium, and which of those have an active Phase 3 trial?

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