Gamma-aminobutyric acid receptor subunit gamma-2

BE0003592ProteinHumansGABRG2

Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:16412217, PubMed:23909897, PubMed:2538761, PubMed:25489750, PubMed:27864268, PubMed:29950725, PubMed:30602789). It is acted on by 12 drugs in DrugBank.

Gene name
GABRG2
UniProtKB entry
P18507Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
475 residues · 55,185 Da
Also known as
GABA(A) receptor subunit gamma-2 · GABAAR subunit gamma-2

Resolves to

Protein
UniProtP18507UniProt nameGBRG2_HUMAN
Gene
HGNCHGNC:4087NCBI Gene2566GenBank31637GeneCardsGABRG2
Pharmacology
KEGGhsa:2566
Structure
PDB6D6TPDB6D6UPDB6HUG
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit gamma-2, how selective are they, and which programs against it are still in active trials?

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