ATP-binding cassette sub-family C member 6

BE0003640ProteinHumansABCC6

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. It is acted on by 11 drugs in DrugBank.

Gene name
ABCC6
UniProtKB entry
O95255Swiss-Prot
Cellular location
Basal cell membrane
Residues / weight
1,503 residues · 164,905 Da
Also known as
7.6.2.- · 7.6.2.3 · Anthracycline resistance-associated protein · ARA · MOAT-E

Resolves to

Protein
UniProtO95255UniProt nameMRP6_HUMAN
Gene
HGNCHGNC:57NCBI Gene368GenBank3928849GeneCardsABCC6
Pharmacology
KEGGhsa:368
Structure
PDB6BZRPDB6BZSPDB6NLO
Drugs

What you can answer from here — as of September 03, 2024

11DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 6, how selective are they, and which programs against it are still in active trials?

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