Ileal sodium/bile acid cotransporter

BE0003643ProteinHumansSLC10A2

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). It is acted on by 16 drugs in DrugBank.

Gene name
SLC10A2
UniProtKB entry
Q12908Swiss-Prot
Cellular location
Membrane
Residues / weight
348 residues · 37,713 Da
Also known as
Apical sodium-dependent bile acid transporter · ASBT · IBAT · Ileal Na(+)/bile acid cotransporter · Ileal sodium-dependent bile acid transporter

Resolves to

Protein
UniProtQ12908UniProt nameNTCP2_HUMAN
Gene
HGNCHGNC:10906NCBI Gene6555GenBank595399GeneCardsSLC10A2
Pharmacology
IUPHAR/GtoPdb960KEGGhsa:6555
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ileal sodium/bile acid cotransporter, how selective are they, and which programs against it are still in active trials?

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