UDP-glucuronosyltransferase 2B17

BE0003680ProteinHumansUGT2B17

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:16595710, PubMed:18719240, PubMed:19022937,... It is acted on by 13 drugs in DrugBank.

Gene name
UGT2B17
UniProtKB entry
O75795Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
530 residues · 61,095 Da
Also known as
2.4.1.17 · C19-steroid-specific UDP-glucuronosyltransferase · C19-steroid-specific UDPGT · UDPGT 2B17 · UGT2B17

Resolves to

Protein
UniProtO75795UniProt nameUDB17_HUMAN
Gene
HGNCHGNC:12547NCBI Gene7367GenBank3287473GeneCardsUGT2B17
Pharmacology
KEGGhsa:7367
Structure
PDB7YAN
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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6Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on UDP-glucuronosyltransferase 2B17, how selective are they, and which programs against it are still in active trials?

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