Matrix metalloproteinase-14

BE0003692ProteinHumansMMP14

Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:8015608). It is acted on by 7 drugs in DrugBank.

Gene name
MMP14
UniProtKB entry
P50281Swiss-Prot
Cellular location
Cell membrane
Residues / weight
582 residues · 65,893 Da
Also known as
3.4.24.80 · Membrane-type matrix metalloproteinase 1 · Membrane-type-1 matrix metalloproteinase · MMP-14 · MMP-X1

Resolves to

Protein
UniProtP50281UniProt nameMMP14_HUMAN
Gene
HGNCHGNC:7160NCBI Gene4323GenBank793763GeneCardsMMP14
Pharmacology
IUPHAR/GtoPdb1638KEGGhsa:4323
Structure
PDB1BQQPDB1BUVPDB2MQS
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Matrix metalloproteinase-14, and which indications are they being tested in?

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