Disintegrin and metalloproteinase domain-containing protein 17

BE0003754ProteinHumansADAM17

Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481, PubMed:38771644). It is acted on by 11 drugs in DrugBank.

Gene name
ADAM17
UniProtKB entry
P78536Swiss-Prot
Cellular location
Cell membrane
Residues / weight
824 residues · 93,020 Da
Also known as
3.4.24.86 · ADAM 17 · CSVP · Snake venom-like protease · TACE

Resolves to

Protein
UniProtP78536UniProt nameADA17_HUMAN
Gene
HGNCHGNC:195NCBI Gene6868GenBank1857673GeneCardsADAM17
Pharmacology
IUPHAR/GtoPdb1662KEGGhsa:6868
Structure
PDB1BKCPDB1ZXCPDB2A8H
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Disintegrin and metalloproteinase domain-containing protein 17, and which indications are they being tested in?

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