Group IIE secretory phospholipase A2

BE0003768ProteinHumansPLA2G2E

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:10681567, PubMed:11922621, PubMed:28883454). It is acted on by 15 drugs in DrugBank.

Gene name
PLA2G2E
UniProtKB entry
Q9NZK7Swiss-Prot
Cellular location
Secreted
Residues / weight
142 residues · 15,989 Da
Also known as
3.1.1.4 · GIIE sPLA2 · Phosphatidylcholine 2-acylhydrolase 2E · sPLA2-IIE

Resolves to

Protein
UniProtQ9NZK7UniProt namePA2GE_HUMAN
Gene
HGNCHGNC:13414NCBI Gene30814GenBank7108923GeneCardsPLA2G2E
Pharmacology
IUPHAR/GtoPdb1419KEGGhsa:30814
Structure
PDB5WZMPDB5WZOPDB5WZS
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Group IIE secretory phospholipase A2, how selective are they, and which programs against it are still in active trials?

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