Mitogen-activated protein kinase 9

BE0003772ProteinHumansMAPK9

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:10376527, PubMed:15805466, PubMed:17525747, PubMed:19675674, PubMed:20595622, PubMed:21364637, PubMed:22441692, PubMed:34048572). It is acted on by 8 drugs in DrugBank.

Gene name
MAPK9
UniProtKB entry
P45984Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
424 residues · 48,139 Da
Also known as
2.7.11.24 · c-Jun N-terminal kinase 2 · JNK-55 · JNK2 · MAP kinase 9

Resolves to

Protein
UniProtP45984UniProt nameMK09_HUMAN
Gene
HGNCHGNC:6886NCBI Gene5601GenBank598183GeneCardsMAPK9
Pharmacology
IUPHAR/GtoPdb1497KEGGhsa:5601
Structure
PDB3E7OPDB3NPCPDB7CML
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase 9, how selective are they, and which programs against it are still in active trials?

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