Mitogen-activated protein kinase 8

BE0003790ProteinHumansMAPK8

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. It is acted on by 17 drugs in DrugBank.

Gene name
MAPK8
UniProtKB entry
P45983Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
427 residues · 48,295 Da
Also known as
2.7.11.24 · c-Jun N-terminal kinase 1 · JNK-46 · JNK1 · MAP kinase 8

Resolves to

Protein
UniProtP45983UniProt nameMK08_HUMAN
Gene
HGNCHGNC:6881NCBI Gene5599GenBank474901GeneCardsMAPK8
Pharmacology
IUPHAR/GtoPdb1496KEGGhsa:5599
Structure
PDB1UKHPDB1UKIPDB2G01
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase 8, how selective are they, and which programs against it are still in active trials?

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