Poly [ADP-ribose] polymerase 2

BE0003798ProteinHumansPARP2

Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231, PubMed:25043379, PubMed:27471034, PubMed:30104678, PubMed:32028527, PubMed:32939087, PubMed:34108479, PubMed:34486521, PubMed:34874266). It is acted on by 12 drugs in DrugBank.

Gene name
PARP2
UniProtKB entry
Q9UGN5Swiss-Prot
Cellular location
Nucleus
Residues / weight
583 residues · 66,205 Da
Also known as
2.4.2.30 · ADP-ribosyltransferase diphtheria toxin-like 2 · ADPRT-2 · ADPRT2 · ADPRTL2

Resolves to

Protein
UniProtQ9UGN5UniProt namePARP2_HUMAN
Gene
HGNCHGNC:272NCBI Gene10038GenBank6688130GeneCardsPARP2
Pharmacology
IUPHAR/GtoPdb2772KEGGhsa:10038
Structure
PDB3KCZPDB3KJDPDB4PJV
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Poly [ADP-ribose] polymerase 2, how selective are they, and which programs against it are still in active trials?

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