NAV

Pamiparib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Pamiparib
DrugBank Accession Number
DB14769
Background

Pamiparib is under investigation in clinical trial NCT03933761 (Pamiparib in Fusion Positive, Reversion Negative High Grade Serous Ovarian Cancer or Carcinosarcoma With BRCA1/2 Gene Mutations If Progression on Substrate Poly ADP Ribose Polymerase Inhibitbor (PARPI) or Chemotherapy).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 298.321
Monoisotopic: 298.122989282
Chemical Formula
C16H15FN4O
Synonyms
  • Pamiparib
External IDs
  • BGB-290

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

ATC Codes
L01XK06 — Pamiparib
Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
8375F9S90C
CAS number
1446261-44-4
InChI Key
DENYZIUJOTUUNY-MRXNPFEDSA-N
InChI
InChI=1S/C16H15FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6,18H,2-4,7H2,1H3,(H,20,22)/t16-/m1/s1
IUPAC Name
(2R)-14-fluoro-2-methyl-6,9,10,19-tetraazapentacyclo[14.2.1.0^{2,6}.0^{8,18}.0^{12,17}]nonadeca-1(18),8,12(17),13,15-pentaen-11-one
SMILES
C[C@]12CCCN1CC1=NNC(=O)C3=C4C(NC2=C14)=CC(F)=C3

References

General References
Not Available
ChemSpider
58805610
ChEMBL
CHEMBL4112930
ZINC
ZINC000150196116
PDBe Ligand
DS9
PDB Entries
7cmw

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentOvarian Cancer1
3Enrolling by InvitationTreatmentAdvanced Malignant Neoplasm1
3Not Yet RecruitingTreatmentOvarian Cancer1
2CompletedTreatmentAdvanced or Inoperable Gastric Cancer1
2CompletedTreatmentHuman Epidermal Growth Factor 2 Negative Carcinoma of Breast1
2Not Yet RecruitingTreatmentOvarian Cancer2
2RecruitingTreatmentCancer1
2RecruitingTreatmentCarcinoma of the Collecting Ducts of Bellini / Clear Cell Papillary Renal Neoplasm / Hereditary leiomyomatosis renal cell carcinoma / Hereditary Papillary Renal Cell Carcinoma / Metastatic Renal Cell Carcinoma ( mRCC) / Metastatic Unclassified Renal Cell Carcinoma / Papillary Renal Cell Carcinoma / Stage III Renal Cell Cancer American Joint Committee on Cancer (AJCC) v8 / Stage IV Renal Cell Cancer AJCC v8 / Tubulocystic Renal Cell Carcinoma / Unresectable Renal Cell Carcinoma1
2RecruitingTreatmentEpithelial Ovarian Cancer1
2RecruitingTreatmentMetastatic Castration-Resistant Prostate Cancer (mCRPC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0933 mg/mLALOGPS
logP2.03ALOGPS
logP1.39Chemaxon
logS-3.5ALOGPS
pKa (Strongest Acidic)10.28Chemaxon
pKa (Strongest Basic)5.62Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area60.49 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity81.01 m3·mol-1Chemaxon
Polarizability29.89 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:26 / Updated at February 21, 2021 18:54