Pamiparib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pamiparib
Accession Number
DB14769
Description

Pamiparib is under investigation in clinical trial NCT03933761 (Pamiparib in Fusion Positive, Reversion Negative High Grade Serous Ovarian Cancer or Carcinosarcoma With BRCA1/2 Gene Mutations If Progression on Substrate Poly ADP Ribose Polymerase Inhibitbor (PARPI) or Chemotherapy).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 298.321
Monoisotopic: 298.122989282
Chemical Formula
C16H15FN4O
Synonyms
Not Available
External IDs
  • BGB-290

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Not Available
Classification
Not classified

Chemical Identifiers

UNII
8375F9S90C
CAS number
1446261-44-4
InChI Key
DENYZIUJOTUUNY-MRXNPFEDSA-N
InChI
InChI=1S/C16H15FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6,18H,2-4,7H2,1H3,(H,20,22)/t16-/m1/s1
IUPAC Name
(2R)-14-fluoro-2-methyl-6,9,10,19-tetraazapentacyclo[14.2.1.0^{2,6}.0^{8,18}.0^{12,17}]nonadeca-1(18),8,12(17),13,15-pentaen-11-one
SMILES
C[[email protected]]12CCCN1CC1=NNC(=O)C3=C4C(NC2=C14)=CC(F)=C3

References

General References
Not Available
ChemSpider
58805610
ChEMBL
CHEMBL4112930
ZINC
ZINC000150196116

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentOvarian Cancer1
3Enrolling by InvitationTreatmentAdvanced Malignancies1
3Not Yet RecruitingTreatmentOvarian Cancer1
2Active Not RecruitingTreatmentAdvanced or Inoperable Gastric Cancer1
2RecruitingTreatmentCarcinosarcoma / Ovarian Cancer1
2RecruitingTreatmentHER2 Negative Breast Cancer / HER2-Negative Breast Cancer1
2TerminatedTreatmentHRD / Metastatic Castration-Resistant Prostate Cancer (mCRPC)1
1Active Not RecruitingBasic ScienceTumors, Solid1
1CompletedBasic ScienceAdvanced Solid Tumors1
1CompletedTreatmentFor Participants With Advanced Solid Tumors Failed With Previous Lines of Treatment1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0933 mg/mLALOGPS
logP2.03ALOGPS
logP1.39ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)10.28ChemAxon
pKa (Strongest Basic)5.62ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area60.49 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity81.01 m3·mol-1ChemAxon
Polarizability29.89 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 08:26 / Updated on June 12, 2020 10:53

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