Calcium/calmodulin-dependent protein kinase type IV

BE0004042ProteinHumansCAMK4

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune... It is acted on by 2 drugs in DrugBank.

Gene name
CAMK4
UniProtKB entry
Q16566Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
473 residues · 51,925 Da
Also known as
2.7.11.17 · CaM kinase-GR · CAMK · CaMK IV · CAMK-GR

Resolves to

Protein
UniProtQ16566UniProt nameKCC4_HUMAN
Gene
HGNCHGNC:1464NCBI Gene814GenBank871845GeneCardsCAMK4
Pharmacology
KEGGhsa:814
Structure
PDB2W4O
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Calcium/calmodulin-dependent protein kinase type IV, and which indications are they being tested in?

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