Rho-associated protein kinase 2

BE0004191ProteinHumansROCK2

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. It is acted on by 13 drugs in DrugBank.

Gene name
ROCK2
UniProtKB entry
O75116Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,388 residues · 160,899 Da
Also known as
2.7.11.39 · KIAA0619 · p164 ROCK-2 · Rho kinase 2 · Rho-associated, coiled-coil-containing protein kinase 2

Resolves to

Protein
UniProtO75116UniProt nameROCK2_HUMAN
Gene
HGNCHGNC:10252NCBI Gene9475GenBank4520225GeneCardsROCK2
Pharmacology
IUPHAR/GtoPdb1504KEGGhsa:9475
Structure
PDB4L6QPDB4WOTPDB5U7Q
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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41GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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52+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Rho-associated protein kinase 2, how selective are they, and which programs against it are still in active trials?

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