Bifunctional chorismate mutase/prephenate dehydratase

BE0004360ProteinEscherichia coli (strain K12)pheA

Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. It is acted on by 1 drug in DrugBank.

Gene name
pheA
UniProtKB entry
P0A9J8Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
386 residues · 43,111 Da
Also known as
5.4.99.5 · Chorismate mutase-prephenate dehydratase · CM · P-protein

Resolves to

Protein
UniProtP0A9J8UniProt nameCMPDT_ECOLI
Gene
NCBI Gene947081GenBank147173
Pharmacology
KEGGecj:JW2580
Structure
PDB1ECM
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bifunctional chorismate mutase/prephenate dehydratase, and which indications are they being tested in?

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